PYRIPROXYFEN 10% EC use can limit insect reproduction by causing adult insect sterilization, reduced egg production, behavior modifications, deformed insects and death. Short‐term dietary and reproduction toxicity data on birds with pyriproxyfen were reported. i.e. High acute risk to aquatic invertebrates and to algae was also indicated for walk‐in tunnels. Agrotechnica is an integrated company that provides complete service of manufacturing, formulation and packing of Crop Protection Products, with a marketing position in the Greek Crop Protection Industry the last 50 years. Pyriproxyfen Mode of action. Finally, for the workers performing harvesting activities in the different crops, no PPE was required according to the EFSA model. In addition, EFSA conducted a public consultation on the RAR. Tier 1‐toxicity and aged‐residue tests on non‐target arthropods, Aphidius rhopalosiphi and Typhlodromus pyri, were available with the representative formulation. A low off‐field risk to A. rhopalosiphi and O. laevigatus was concluded for all the representative uses, based on the available data. Screening assessments for solitary bees were also performed (acute adult, chronic adult, and larva). Surface tension studied at highest use‐in concentration (relevant for all representative uses evaluated; see Section, Accelerated storage stability study (relevant for all representative uses evaluated; see Section, Verification of the extraction procedure used in the monitoring method in dry and high oil content matrices (relevant for all representative uses evaluated; see Section, Analytical method for monitoring of pyriproxyfen residues in body fluids (relevant for all representative uses evaluated; see Section, Further information and assessment of the analytical methods used in support of the (old) toxicity studies (relevant for all representative uses evaluated; see Section, For a complete literature review, the exclusion of articles after full‐text assessment should be further justified (with the support of more detailed assessment of the full‐text articles) (relevant for all representative uses evaluated; see Section, Since pyriproxyfen is an UVB absorber, the, Storage stability data for pyriproxyfen residues on a commodity representative of the pome fruit crop group (relevant for the representative use on apples and pears evaluated; see Section, One additional residue trial on tomatoes compliant with the SEU outdoor GAP (relevant for the representative use on tomatoes evaluated; see Section, Information on potential conversion/preferential degradation of isomers of pyriproxyfen in soil and water under illuminated conditions and in the water/sediment systems (concluded as not being necessary to conclude on the risk to terrestrial vertebrates and non target organisms for the representative uses evaluated; see Sections, Information on potential conversion/preferential degradation of isomers of metabolites DPH‐Pyr (aquatic compartment only), 4’‐OH‐Pyr and PYPAC in the environmental compartments PYPAC (concluded as being necessary to conclude on the chronic risk assessment to aquatic invertebrates for metabolite PYPAC only for the representative uses evaluated; see Sections, Information to address the risk to sediment‐dwelling organisms was not available and therefore a low risk could not be concluded for exposure via the sediment phase (relevant for all representative uses evaluated; see Section, Information to address the risk to honeybee larvae (relevant for all outdoor uses evaluated; See Section, Information to further address the risk to bees from the outdoor use on ornamentals (relevant for all outdoor uses evaluated; see Section, Information to address the risk from sublethal effects to bees (relevant for all outdoor uses evaluated; See Section, Information to address the effect of water treatment processes on the nature of residues present in surface water, when surface water is abstracted for drinking water was not available. A final consultation on the conclusions arising from the peer review of the risk assessment and on the proposed MRLs took place with Member States via a written procedure in April–May 2019. Metabolite 4’‐OH‐Pyr exhibited low to slight soil mobility, metabolite PYPAC exhibited very high soil mobility and metabolite DPH‐Pyr (a major metabolite in the aquatic compartment) exhibited medium to low soil mobility. 2‐OH‐PY and 4’‐OH‐PYR (free and sulfate conjugates) were identified at relevant proportions (> 10% TRR) in eggs, liver, muscle and fat. The developmental NOAEL was 100 mg/kg bw per day based on increased incidences of visceral malformations at 300 mg/kg bw per day, not reproducible at the high dose (1,000 mg/kg bw per day) since an insufficient number of dams was present for evaluation. Low risk to birds and mammals from exposure to contaminated water and via secondary poisoning was indicated for all the representative uses. For the rabbit developmental toxicity, the maternal NOAEL was 100 mg/kg bw per day based on increased abortions and/or premature deliveries. Pyriproxyfen 10% + Bifenthrin 10% w/w EC: M/s Parijat Industries (India) Pvt. 4.5 out of 5 stars 29. The PEC in soil, surface water, sediment and groundwater covering the representative uses assessed can be found in Appendix A of this conclusion. PYRIPROXYFEN 10% EC use can limit insect reproduction by causing adult insect sterilization, reduced egg production, behavior modifications, deformed insects and death. However, this information was not available for metabolites 4’‐OH‐Pyr, PYPAC and DPH‐Pyr, which contain chiral carbon atom, and to address the specific environmental behaviour of the single isomers of pyriproxyfen under illuminated conditions. Having regard to the low to moderate persistence of pyriproxyfen in soil (laboratory DT90: 11–135 days), rotational crops metabolism studies are triggered. 2011-07-18T12:20:47-04:00 Pyriproxyfen residues in soil and air can be monitored by gas chromatography with nitrogen–phosphorus detector (GC‐NPD) with LOQs of 0.01 mg/kg and 1 μg/m3, respectively. Tomato crop has no melliferous capacity according to the current guidelines (European Commission, 2018). ca. The SWAN tool (version 4.0.1) was appropriately used to implement these mitigation measures in the simulations. Pyriproxyfen is a racemic mixture of an (R)‐enantiomer and an (S)‐enantiomer. … The representative uses evaluated were foliar spray applications for control of scales in citrus and pome fruits and … In addition, the consumer risk assessment is not finalised considering the lack of appropriate information to address the effect of water treatment processes on the nature of residues potentially present in surface water, when surface water is abstracted for drinking (see Sections, The chronic risk assessment to aquatic invertebrates for the pertinent aquatic metabolite PYPAC, could not be finalised (see Sections, The risk assessment to sediment‐dwelling organisms from exposure via the sediment could not be finalised (see Sections, The risk assessment for bees from the field use on ornamentals (see Section, The risk assessment for sublethal effects to honeybees could not be concluded (see Section, The superscript numbers relate to the numbered points indicated in Sections, Collaborative International Pesticides Analytical Council Limited, period required for 50% dissipation (define method of estimation), period required for 90% dissipation (define method of estimation), Oestrogen, androgen, thyroid or steroidogenic, Food and Agriculture Organization of the United Nations, Forum for the Co‐ordination of Pesticide Fate Models and their Use, high‐pressure liquid chromatography with tandem mass spectrometry, International Organization for Standardization, International Union of Pure and Applied Chemistry, Joint Meeting of the FAO Panel of Experts on Pesticide Residues in Food and the Environment and the WHO Expert Group on Pesticide Residues (Joint Meeting on Pesticide Residues), Freundlich organic carbon adsorption coefficient, liquid chromatography with tandem mass spectrometry, Organisation for Economic Co‐operation and Development, predicted environmental concentration in air, predicted environmental concentration in groundwater, predicted environmental concentration in sediment, predicted environmental concentration in soil, predicted environmental concentration in surface water, pF value of 2 (suction pressure that defines field capacity soil moisture), quantitative structure–activity relationship, simplified molecular‐input line‐entry system. Pyriproxyfen was shown to be stable under frozen conditions for up to 12 months in tomatoes (high water content matrices), 4 months in oranges (high acid content matrices) and 13 months in cotton seed (high oil content matrices). View this supplier’s website Appendix A can be found in the online version of this output (‘Supporting information’ section): https://doi.org/10.2903/j.efsa.2019.5732, 4‐phenoxyphenyl (RS)‐2‐(2‐pyridyloxy)propyl ether, CC(OC1=NC=CC=C1)COC2=CC=C(OC3=CC=CC=C3)C=C2, 4‐(4‐{2‐[(pyridin‐2‐yl)oxy]propoxy}phenoxy)phenyl β‐D‐glucopyranosiduronic acid, O[[email protected]]1[[email protected]@H]([[email protected]@H](C(O)=O)O[[email protected]]([[email protected]@H]1O)OC2=CC=C(OC3=CC=C(OCC(OC4=NC=CC=C4)C)C=C3)C=C2)O, 4‐(4‐(2‐(pyridin‐2‐yloxy)propoxy)phenoxy)phenol, CC(OC1=NC=CC=C1)COC2=CC=C(OC3=CC=C(O)C=C3)C=C2, 4‐(4‐(2‐(pyridin‐2‐yloxy)propoxy)phenoxy)phenyl hydrogen sulfate, CC(OC1=NC=CC=C1)COC2=CC=C(OC3=CC=C(OS(O)(=O)=O)C=C3)C=C2, European Food Safety Authority, In addition to the acute data, appropriate chronic data were available for adult honeybees and larvae with the active substance. 8.9% AR) exceeded 5% AR in at least two consecutive sampling dates in the degradation experiments; therefore, it was included in the present assessment. Toluene was identified as a toxicologically relevant impurity with a maximum acceptable level of 5 g/kg. Sample analyses were carried out also for metabolites PYPAC and 4’‐OH‐Pyr. The representative formulated product for the evaluation was ‘Pyriproxyfen 100 g/L EC’, an emulsifiable concentrate (EC) containing 100 g/L pyriproxyfen. . $48.94 $ 48. With regard to the assessment of the endocrine‐disrupting (ED) potential of pyriproxyfen according to the ECHA/EFSA guidance (2018), the Oestrogen, androgen, thyroid or steroidogenic (EATS)‐mediated parameters were considered as not being sufficiently investigated in routine toxicological studies where evidence of EATS‐mediated adverse effects was not observed. The data available on environmental fate and behaviour were sufficient to carry out the required environmental exposure assessments at the EU level for the representative uses, with the notable exception that the consumer risk assessment from the consumption of drinking water could not be finalised for all the representative uses since information on the effect of water treatment processes on the nature of residues of both the active substance and its identified metabolites potentially present in surface, when surface water is abstracted for drinking water was insufficient. 6/13/2011 Avoid contact with eyes, skin and clothing. Pyriproxyfen residues in surface water can be analysed by QuEChERS LC–MS/MS with a LOQ of 0.001 μg/L and in drinking water by gas chromatography with mass spectrometry (GC–MS) with a LOQ of 0.1 μg/L. Also in this case, the potential for groundwater exposure above the parametric drinking water limit of 0.1 μg/L was concluded to be low for pyriproxyfen and its metabolites. Adequate methods are available for the generation of data required for the risk assessment except for the (old) toxicological studies, for which no information was submitted (data gap). Also used for control of whitefly and thrips. Pesticide Product Label, -, CONTROL SOLUTIONS, INC., 5388300280 In the area of residues, the consumer dietary risk assessment cannot be finalised in view of the identified data gaps. However, for the chronic risk assessment to aquatic invertebrates for metabolite PYPAC and the acute risk assessment to fish for metabolite 4’‐OH‐Pyr, this data gap resulted in an assessment not finalised due to the insufficient margin of safety between hazard endpoints and predicted environmental concentrations (PEC) indicated in the available environmental risk assessments. Since the parent pyriproxyfen was the major compound of the total residues in all crops, the residue definition for monitoring and risk assessment is proposed as pyriproxyfen only for fruit and pulses/oilseeds crops following foliar treatment. Cyper10-Cypermethrin 10% ECCypermethrin is a synthetic pyrethroid used as an insecticide in large-scale commercial agricultural applications as well as in consumer products for domestic purposes. OJ L 155, 11.6.2011, p. 127–175. It is noted that the metabolites 4’‐OH‐PYR and PYPAC have very low to moderate persistence (max. Since only seven GAP‐compliant residue trials on tomatoes (SEU outdoor GAP) are available, one additional residue trial on tomatoes is requested to complete the SEU outdoor residue data set (data gap). It is noted that according to the current guidelines storage stability data on a commodity representative of the pome fruit crop group are also required in order to support the representative use on apples and pears and covering the maximum storage time interval of the residue samples from the submitted trials on apples (data gap). 2011-06-21T13:38:50Z For ruminants and for both labellings, pyriproxyfen was extensively degraded in milk, liver and kidney (< 1–15% TRR) with 4’‐OH‐PYR (free and sulfate conjugates) being predominant in those matrices (18–53% TRR), 2,5‐OH‐PY (conjugate) in milk (30% TRR), POPA in liver (16% TRR) and POP sulfate conjugate in kidney (36% TRR). Any queries (other than missing content) should be directed to the corresponding author for the article. Information on its repeat‐dose toxicity was not available. In accordance with Article 1 of the Regulation, the RMS the Netherlands and co‐RMS Spain received an application from Sumitomo Chemical Agro Europe for the renewal of approval of the active substance pyriproxyfen. The minimum purity of the technical material is 970 g/kg. Via Carlo Magno 1A, 43126 ca. High risk is indicated for the soilless greenhouse use in ornamentals and for walk‐in tunnels (open). Daita inhibits metamorphosis of … Pyriproxyfen Available formulation. The risk assessment was based on the following documents: European Commission (2002a,b), SETAC (2001), EFSA (2009), EFSA PPR Panel (2013) and EFSA (2013). Regulator ; suppressor of embryogenesis, inhibitor of reproduction stages of whitefly Pest in cotton seed and gin,... To moderate persistence to algae was concluded that no photodegradation products required further in! Metabolites identified at a level > 10 % EC may be used an. Studies, pyriproxyfen 10 % w/w + … UNIVERSAL pyriproxyfen 100 EC data... 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Of Regulation ( EU ) no 396/2005 on honeybees were available with the available data and quantitative assessments.